Summary statistics (mean ± SD and number of subjects) for demographic and baseline characteristics were calculated, and either a χ2 test of independence or a 2-sample t test was used to assess differences between treatments for each demographic characteristic. This study was sponsored by Alcon Research, Ltd, Fort Worth, Tex. In the present study, we compared the effectiveness of 2 marketed ceruminolytic products, Cerumenex Eardrops and Murine Ear Drops, with a saline placebo, BSS Sterile Irrigating Solution, in a controlled clinical setting, in which duration of treatment and method of irrigation were held constant. Motion Sickness Prevention. See the "Methods" section for a description of Cerumenex, Murine, and placebo products. Ear wax removal bay area. Excessive earwax in the external auditory canal is a common problem in clinical practice. Training in the use of specialized equipment is required; mechanical removal is potentially damaging to the ear structures if conducted incorrectly. We serve patients from El Cajon CA, Wells Park CA, Rancho San Diego CA, Hillsdale CA, Alpine CA, Santee CA, and Jamul CA. The change from baseline degree of occlusion to a resolved, improved, or unchanged/worsened condition is depicted in Figure 1. Sinus Infections and Congestion. Poison Ivy, Poison Oak.
We used a 4-point degree of occlusion scale and found it helpful in differentiating between the severity of occlusions before, during, and after treatment, which allowed us to compare the effectiveness of the test articles. Neither Cerumenex nor Murine was superior to saline placebo. 7% of subjects treated with Cerumenex, Murine, and placebo, respectively, experienced resolution of cerumen occlusion and/or impaction. Although we do not know why there was a higher incidence of success in the saline arm of this study, one may speculate that an aqueous solution such as saline may be more effective in softening the cerumen because it produces swelling of the epithelial components of a cerumen impaction, loosening and separating these components from each other. Ear wax removal sacramento. Walgreens Pharmacy administers applicable vaccinations for children ages three and older. All clinical assessments were performed by a qualified specialist. You do not have a primary care physician. You are away from home. 10 Further assessment of the ceruminolytic properties of saline might potentially be done using comparators such as pure water or no pretreatment in a controlled clinical setting.
Of 24 occlusions treated with Cerumenex, 2 (8%) cleared after 1 treatment; of 26 occlusions treated with Murine, 3 (12%) cleared after 1 treatment; and of 24 occlusions treated with placebo, 2 (8%) cleared after 1 treatment. 2004;130(10):1175–1177. Family Practice Clinic – East County Urgent Care. Therefore, in an effort to evaluate the effectiveness of currently available ceruminolytic agents, we compared representative prescription and over-the-counter products with a placebo in a controlled clinical setting. Randomized, Placebo-Controlled Evaluation of Cerumenex and Murine Earwax Removal Products | Otolaryngology | JAMA Otolaryngology–Head & Neck Surgery | JAMA Network. 5% carbamide peroxide; Abbott Laboratories, Abbott Park, Ill), or placebo (BSS Sterile Irrigating Solution, a saline preparation containing 0. No statistically significant differences between demographic factors (age and sex) or between baseline degree of occlusion levels were observed between treatment groups. The distinction between mild and moderate levels of occlusion, however, is more subjective. Otologic signs and symptoms were also assessed. While in many instances earwax can be removed mechanically, specialized instruments such as operating microscopes, suction, and/or flushing equipment may not be available in a primary care setting. We can see you for your cough and cold when your primary physician is not available. 1 It can also impede proper otologic examination, hearing and balance testing, and the effective use of hearing aids.
Efficacy was based on the posttreatment level of occlusion. Analyses that were performed were done post hoc. This was a randomized, observer- and subject-blind, placebo-controlled, 1-day trial in volunteers with excessive or impacted cerumen. Customize your JAMA Network experience by selecting one or more topics from the list below. On site limited laboratory services. 3 -7 Differences in effectiveness can perhaps be attributed to differences in treatment regimen, including the duration of treatment and the volume and pressure of irrigation following application of the softening agent. Roland PS, Eaton DA, Gross RD, et al. 5% carbamide peroxide), and a placebo, BSS Sterile Irrigating Solution (Alcon Laboratories Inc, Ft Worth, Tex). As required by editorial policy, an independent statistician, William Frawley, PhD, Department of Statistics, University of Texas Southwestern Medical Center, Dallas, reviewed the data, and his analysis confirmed the statistical evaluation. It is generally accepted that cerumen removal is a commonly performed, time-consuming procedure that carries added risk if mechanical means or lengthy irrigation procedures are required. Accumulated earwax can cause discomfort, temporary hearing loss, occasional cough or vertigo, and can promote infection.
It looks like the version of the browser you're using is unsupported. 5%) required 2 applications, whereas 9. Return To Duty Physical. The test medication was instilled into 1 occluded ear for up to two 15-minute applications. Signed written informed consent was obtained from all subjects in advance of any study procedures. Because full visualization of the tympanic membrane is the ultimate goal of many cerumen removal procedures, the scale was based on the assessor's ability to visualize the tympanic membrane, rather than on the amount of cerumen present or removed. 9 The study concluded that oral jet irrigators were a safe method of cerumen removal but that only the lowest settings should be used. To maintain masking of the clinical assessor and subject, test articles were stored out of view and were administered by clinic staff who did not perform clinical assessments. We can report all tests and progress notes to your primary care physician upon request so they have a history of what was done at East County Urgent Care Center in El Cajon. We found the scale, with its qualitative descriptions of occlusion levels, to be effective, particularly in differentiating between complete, mild or moderate, and no occlusion. Our Urgent care clinic in El Cajon California, is a convenient solution to illness, injury, minor emergency or other health care needs, and is an excellent alternative to the emergency room for all your non-life threatening medical conditions requiring immediate care and medical attention. Because this was planned as a descriptive study, no power calculations were made prior to study initiation.
Currently marketed ceruminolytic products primarily act by softening earwax to facilitate its removal with irrigation, rather than by dissolution. Services provided in our Urgent care center are low cost with a short wait time (Immediate Care), compared to the expensive cost and long wait time provided in any emergency room. Cold Sores, Canker and Mouth Sores. Study participants were company (sponsor) employees and were recruited via an intracompany advertisement to participate in an earwax removal study. The study design also replicated actual use of a ceruminolytic product in an outpatient clinic setting. Occlusion level was reassessed after each application of medication or placebo and after each irrigation procedure. Participants had baseline occlusion levels of mild (n = 10), moderate (n = 26), or complete (n = 38) impairment of tympanic membrane visualization. Our family care physician at East County would be delighted to begin a fruitful medical relationship with you and your family! Upper Respiratory Infections. Please consider updating your browser. Vaccines are subject to availability; certain vaccines may not be available in all stores. Corporate research clinic. We can treat you for all of your colds, allergies, annual physicals, and even treat you for diabetes, hypertension, hypothyroidism.
These values were not statistically significantly different from one another. Zocdoc no longer supports Internet Explorer. Of 230 volunteers screened, 74 qualified for enrollment. Subjects were randomly assigned to 1 of 3 treatments: Cerumenex Eardrops (10% triethanolamine polypeptide oleate-condensate; Purdue Frederick Company, Norwalk, Conn), Murine Ear Drops (6. Accepted for publication June 15, 2004. The senior author (P. R. ) directed a study on the effect of oral jet irrigation on the tympanic membrane in fresh cadavers.
One-Time Medication Refills. Subjects were required to be 18 years or older and to have mild, moderate, or complete cerumen occlusion, as measured against a previously established 4-point scale (Table 1). By providing the information below, you'll be able to select from a specific list of vaccines the patient can schedule at Walgreens. Descriptive statistics were calculated for (1) the proportion of subjects in each degree of occlusion category at the end of treatment by baseline severity and (2) the proportion of subjects who obtained resolution of their occlusion relative to the subjects who did not obtain resolution. Following the treatment, the subject's ear was irrigated with 50 mL of lukewarm water delivered at low pressure via a WaterPik irrigator equipped with a Grossan irrigator tip.
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